![]() ![]() The authors highlight the similarities and variations of the guidelines for validation of bioanalytical methods issued by the main regulatory agencies in the world (United States Food and Drug Administration - USFDA, European Medical Agency - EMA, Brazilian Agency for National Health Surveillance - ANVISA, and the Ministry of Health, Labour and Welfare - MHLW, Japan) and that the diffusion of these validation regulatory standards assists in the quality of the food and drug production process, resulting in a product with better hygienic-sanitary profiles, stability, resistance to temperature variations and increased expiration date (degradation time) of such product. ![]() An Invitation to Applied Mathematics: Differential Equations, Modeling and Computation, Academic Press: San Diego, 2016.Īn important fact is the role of regulatory agencies in different countries in the production of drugs and food, and in the guidelines for the validation and use of different bioanalytical techniques for this purpose. Engineering Mathematics with Examples and Applications, Academic Press: San Diego, 2017. The validation of a model or method used in the description and explanation of a phenomenon depends mainly on information and data obtained experimentally, since the model or the method functions as a theoretical representation of a fact / phenomenon. Use of computational models for prediction of a certain phenomenon is an important stage of the scientific method, since the quantification of variables and the prediction of how the event can be processed are important information that help in the elucidation of the mechanism (detailed steps) by which such phenomenon occurs. Universidade Federal Rural da Amazônia, Rua João Pessoa, 121, Campus Capanema Centro, 68700-030 Capanema - PA, Brasil About the authors Juscelino Kubitschek, Km 02, s/n, Jardim Marco Zero, 68902-280 Macapá - AP, Brasil Carlos Henrique Tomich de Paula da SilvaĮscola de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto - SP, Brasil Williams Jorge da Cruz Macêdo Juscelino Kubitschek, Km 02, s/n, Jardim Marco Zero, 68902-280 Macapá - AP, Brasil Ryan da Silva Ramosĭepartamento de Ciências Biológicas, Universidade Federal do Amapá, Rod. Juscelino Kubitschek, Km 02, s/n, Jardim Marco Zero, 68902-280 Macapá - AP, Brasil Karina da Silva Lopes Costaĭepartamento de Ciências Biológicas, Universidade Federal do Amapá, Rod. Universidade Federal do Pará, Rua Augusto Corrêa, 1 - Guamá, 66075-110 Belém - PA, BrasilDepartamento de Ciências Biológicas, Universidade Federal do Amapá, Rod. *e-mail: Cleydson Breno Rodrigues dos Santos
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